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What if we were immune to AIDS?

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Image: A zinc finger nuclease clips the CCR5 gene out of a T-cell. Courtesy Sangamo Biosciences.

Some people have a mutation that makes them amazingly resistant to HIV — and now, scientists may have found a way to give that immunity to anyone.
Viruses enter cells and take them over, but to get inside, they need a handhold. HIV pulls itself in by grabbing onto a protein called CCR5, which decorates the surface of T-cells, which are one of the two major types of white blood cells and play an important role in helping the body fight infections. Back in the 1990’s, researchers took interest in a handful of promiscuous gay men who were able to engage in sexual relations with their HIV-positive partners with impunity. Most of them had a mutation that kept their cells from producing normal CCR5 protein.
Armed with that knowledge, scientists have developed several tactics to block the production of CCR5 or perturb its shape so that the HIV virus can’t grab onto it during the first step of its hijacking attempt. The strategy is much akin to cutting your hair before a wrestling match: It gives your opponent one less thing to grab onto.
In the latest version of this defense, Carl June and his colleagues at the University of Pennsylvania used a highly engineered protein, called a zinc finger nuclease, to clip the CCR5 gene out of some T-cells. Left without the recipe for that protein, the cells are nearly impenetrable. His report appeared on the Nature Biotechnology website yesterday.
June tested the procedure on cultured T-cells and mice — not humans — so it should be a source of guarded optimism, because it’s not certain the technique would work in humans. In theory, AIDS doctors could take some T-cells out of an infected person, edit their genomes, and stick them back into their patient. Once they have returned to the body, each resistant cell will thrive and multiply in spite of the disease. This trick would not eliminate the virus, but it might be able to permanently raise the T-cell counts of AIDS patients, increasing their ability to resist secondary infections and remain healthy.

Source: Wired

What If…? An alternative history of the world

What if the dinosaurs had survived? Or Hitler won in 1945? Or the airplane had been invented 1,000 years earlier? Would there even be life on earth if the moon had failed to form? Science fiction writer Stephen Baxter canvasses the possibilities.

4.5 billion years ago: The Moon never formed

Life on Earth is very different; that is, if there’s any life at all

The young Earth was wrapped in a blanket of cloud. Through a hierarchy of impacts, cloud particles gathered into whizzing asteroid-like bodies. The collisions were spectacular; Earth’s final visitor was the size of Mars. Where the planets touched, a ring of fire formed, shattering the surface of both. Liquid rock gushed into space, and a glowing ring coalesced in orbit. Our Moon was born. Without it, and the gradual slowing of the tides, Earth’s day would be about eight hours. The air would be rich in oxygen but laden with carbon dioxide. Given the fast rotation, there would be violent winds andno trees. Animals would need strength, armour, low profilesand would have fast metabolisms. The Moon stabilised Earth’s rotation. Moonless Earth would have dramatic climate shifts - droughts, floods and ice ages.

65 million years ago: The dinosaur extinction does not happen

Earth is spared collision with asteroid

Sixty-five million years ago, the dinosaurs still ruled land and sea, as they had for more than 100 million years. Then a comet or asteroid struck our planet, wiping out 60 to 80 per cent of all species. Earth was unlucky to have been hit so late in its evolution. With no impact, the climate would have continued to evolve, species to rise and fall. Intelligence could have arisen, among birds or mammals, so they relied on brains rather than brute strength. One day, something similar to humans might have faced something like the dinosaurs. But we were hit and, although dinosaurs succumbed, some rat-like mammals dug themselves into the ash and survived.

476: Rome never falls

A Roman industrial revolution drives a unifying empire

Did Rome have to fall? After military defeats, the emperors tried to establish “natural boundaries”, such as the Rhine and Hadrian’s Wall, thus halting the empire’s growth and economic development. They were technologically advanced and came close to the invention of steam engines. But such things were treated only as toys, and the chance of a Roman industrial revolutionwas lost.

If Rome had survived it might have fought off Islam where Byzantium failed, and handled the Mongols better than their medieval successors. In the Americas they wouldn’t have practiced genocide as the British did, but assimilated, in the Roman way. In Europe, united in empire, there would be no feudalism, no chivalry - no parliaments - and no Great Britain.

875: Flight discovered 1,000 years early

Medieval Muslims use aircraft to conquer Europe

Just seven decades after the Prophet’s death, Islamic armies swept across north Africa, and from 711AD conquered Spain. Abbas Qasim Ibn Firnas was a Cordoban scholar who, aged 70, built a flying machine. The old man glided off a mountain. His machine lacked a tail; he landed hard, hurting his back. But if he had succeeded, the Moors could have harnessed their edge in technology to wage war on western Europe. Rapid expansion would, most likely, have extinguished western Christendom. And in a Moorish London, blond Saxon children would have learned the revelation of Mohamed.

1348: The Black Death is averted

Lives are saved, but at what cost to freedom?

In the 14th century, the Black Death came out of the heart of Asia. It affected all of Europe within a few years. In cities such as London, half the population died. It was monstrous, but the plague had first appeared in Europe in Roman times, so populations had some resistance. In all, just (just!) a third of Europeans were killed by the Black Death. Compare that to 95 per cent of native North Americans killed during the European conquests by measles, smallpox and plague - diseases to which they had no prior exposure. But could the Black Death have been averted? Arabic doctors had an understanding of hygiene, for example, far in advance of western European medicine. What if the Death had been stopped or diluted?

In the emptied world after the Death, the feudal systems came under strain. Suddenly there were too few folk to do the work; a bad lord could not keep employees. Prices changed as the population drop meant there was more than enough food. There were revolts as the rulers tried to regain control. The relationship of rulers to ruled was transformed, and the slow opening-up of the medieval world began. Our modern freedoms came out of the vast charnel house that was the Black Death.

1441: Chinese explorers discover America

The New World is found, 50 years before Columbus

At the time of the 15th-century early Ming Dynasty, the Chinese - who led the world in printing, gunpowder and navigation - went exploring. A Muslim eunuch from the Yunnan Province, called Zheng He, assembled a great exploratory navy. The first westward expedition, seeking new trading relationships, set off in 1405 (15 years ahead of the first great Portuguese voyages of discovery). The Chinese vessels were “treasure ships”, the biggest 400ft long and weighing 1,500 tons - decades ahead of anything in the west. His first expedition, which reached India, comprised 62 vessels carrying 28,000 men. In all, Zheng He made seven westward voyages, bringing home exotic novelties and striking terror and awe wherever he landed.

Zheng He could have beaten Columbus to the Americas but went home because of politics. The eunuch’s voyages were seen as a threat by the Confucian scholars who ran the imperial bureaucracy. In 1436 the Confucians convinced the Emperor that China didn’t need to deal with barbarian lands.

Source: independent

What if the Combined Fleet Went to Oahu?

How could Japan have bombarded the Fortress of the Pacific ?

Since the Combined Fleet didn’t historically do much in it’s distant support of the Kido Butai’s effort against Oahu, I’d like to propose a “what if” discussion about what they might have done, instead.

I know that there are a multitude of historical reasons for why such an alteration in history could not have happened but, I’d like, with your agreement, to …

1.) … leave aside the entire “Japanese strategic doctrine would never have allowed that” discussion/debate and just assume that somehow/someway, it was so ordered. Maybe Emperor Hirohito had a dream … about conducting the Decisive Battle of the Pacific War off of Hawaii ?

2.) Likewise, I’d like to sidestep the entire “the IJN didn’t have the logistics base to support a move by the Combined Fleet to Oahu” discussion/debate. I know and accept that already but would like to have a bombardment discussion and so have assumed that the fuel/supplies/ammo would be provided, somehow/somewhere, like manna from heaven.

Actually, my pet theory is that Japan might have used many of the high speed modern tankers idled by the American led oil embargo against her, to re-fuel the Combined Fleet as it headed east. Historically they did so convert, to underway re-fueling status, some of those tankers otherwise anchored in the Inland Sea. In effect, creating more last minute and poorly trained fleet oilers, in great secrecy. Since they did it historically, I don’t think it too much of a “mental stretch” to assume that 3.) they could have so converted more in the time that they had available. With the a similar degree of success and secrecy.

So, if you agree, the IJN’s Combined Fleet, less the two battlecruisers historically sent south in support of the Southern Operation, crosses the northern Pacific just behind the Kido Butai, having also left it’s usual radio operators back in Japan to transmit fake messages from there.

————————————————————————-
Now, some map homework for you, the reader,

Pre-mission scouting on Oahu by Yoshikawa would have revealed that the map found at http://militarymaps.org.ua/maps/ospr…_008/map9.djvu is far too optomistic for Dec.’41. (You’ll need the Djvu viewer which is available for free download at djvu.com to see that map). The map, by C.Taylor, comes from the Osprey book entitled “Defenses of Pearl harbor and Oahu 1907-50″ by Williford & McGovern

First, you’ll have print out a copy and then erase all of the black firing arcs because those batteries were built after Dec.7′41. Next go the browns for a similar reason. Finally the purple #6 arc gets converted to a 360 degree circle to more properly show its real 16″ firing abilities on Dec.7′41. The existing purple arc shows it’s casemated firing arc after it was fortified circa late 1942.

Do the same for purple arc #5 for battery Closson. In 1941 it too could fire 360 degrees, not just a forward arc.

Not nearly so impressive a defensive map of US 8″ and larger coastal artillery firepower now, is it ?

Source: alternatehistory.com

What If…

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SEARCH for the past unearthed a future of friendship for these long-lost cousins.
When Yvonne Anderson enrolled on an evening class to trace her family tree she was hoping to delve into the past and discover her ancestors.
What she was not expecting to find was a cousin she never knew existed – sitting across the table from her on the very same course.
And she discovered that she and cousin Joyce Bell had grown up just a few miles away from each other in Newcastle’s East End, but their paths had never crossed.
And as the pair chatted they realised they’d both grown up in the East End and now live just a few miles away from each other.
Mrs Anderson, a 61-year-old widow and grandma-of-two, said: “I started the ‘trace your family tree for beginners’ course at Fenham Library in January.
“At our first class we introduced ourselves and said which family name we were going to research. I was looking into the name Greenall, from Cumbria, and the lady sitting opposite me said she was looking for that name too.
“At the time we just laughed and said ‘I wonder if we’re related’, but we were amazed to find our grandfathers were brothers, making us second cousins.
“We were about six weeks into the course before we found out we were related, but the more I saw Joyce the more I thought she resembled my auntie.”
Mrs Anderson now meets up with her new-found relation every Saturday morning at the library where they are working to produce an online family tree.
And after discovering just how similar their lives have been, they are surprised their paths had not crossed sooner.
Mrs Bell, a 68-year-old widow and mum to Glenn, 41, and Joyce, 43, was born and grew up in Walker, while Mrs Anderson spent the first part of her childhood a stone’s throw away in Byker, before her family moved to Fawdon when she was nine.
Mrs Anderson now lives on Etal Park Estate and Mrs Bell lives just a few miles away in Blakelaw – just one street away from Mrs Anderson’s only child, Kelly, and her two children, Keelan, three, and baby Kaila.
Mrs Bell said: “It’s just incredible we found each other; lovely really, and we will definitely keep in touch.
“We have started a more advanced family history course and we’re going through library archives, army and war records and lots of books.
“It can be quite tricky, but I think I’ve found my great-grandparents and I’ve gone back as far as 1840. In those days not everyone could write properly, so the records we’ve found are not always that clear.
“It’s been so interesting and I’m very pleased I started the course. I joined out of sheer curiosity. I’ve always liked looking at local history.
“It would be great if our story could inspire other people to look into their family history. It’s been a lot of fun and some people may find relatives they never knew they had, just like us.”
Mrs Anderson has now started to produce the family tree on the website Genes Reunited and hopes to keep adding to it.
The women’s story has delighted the staff at Fenham Library.
Caroline Miller, head of adult learning for Newcastle City Council, added: “There are all sorts of benefits to be gained from an adult learning course.
“They can help you catch up on skills not learnt at school, to improve your job prospects or they could just be for a bit of fun.
“Joyce and Yvonne’s story is the first time I’ve heard of someone uncovering unknown family members.”

Source: chronicle live

What if your odds were 1 million to one to survive?

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In Australia, Durga Thangarajah, survived 9 months in her mother’s ectopic pregnancy. Doctors said Durga Thangarajah is a 1 million to one occurrence.

Durga Thangarajah, born to Ravi Thangarajah, and Meera Thangarajah, appeared healthy. Durga Thangarajah weighed 6 pounds, 3 ounces (2.8 kilogramsDurga Thangarajah was delivered by Caesarian operation. Obstetrician Andrew Miller said that Durga Thangarajah was a lucky, miracle baby. Intially, he disbelieved that it was possible for the baby to be carried to full term. Mother and child did not suffer from any symptoms.

Durga Thangarajah’s mother, Meera Thangarajah, went for her usual pregnancy tests and ultra scan but those failed to detect anything wrong. If she and her doctors would have known about her ectopic pregnancy, she would be advused to end it. An ectopic pregnancy poses a life and death danger to both the baby and mother.

Durga Thangarajah and Meera Thangarajah were in Darwin hospital. They already have a daughter, Gayatri, aged 6.

Source: celeb galz